Overview

  • Product nameAnti-CD51 + CD61 antibody [23C6]
    See all CD51 + CD61 primary antibodies
  • Description
    Mouse monoclonal [23C6] to CD51 + CD61
  • SpecificityReacts with CD51 and CD61. 23C6 may be useful for bone resorption modulation, osteoclast identification, receptor purification, malignant melanoma identification and treatment.
  • Tested applicationsSuitable for: Flow Cyt, IP, Neutralising, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Cell preparation: A cell suspension containing osteoclasts from osteoclastomas.

  • Positive control
    • Positive control: Tonsil. 125/124 kDa (reduced), 150kDa (non-reduced).

Properties

Applications

Our Abpromise guarantee covers the use of ab20143 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
IP
Neutralising
IHC-Fr
  • Application notesFlow Cyt: Use at an assay dependent dilution.
    IHC-Fr: Use at an assay dependent dilution.
    Note: samples should be acetone fixed.
    IP: Use at an assay dependent dilution.
    Neut: Use at an assay dependent dilution.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceIntegrins are integral cell-surface proteins composed of an alpha chain and a beta chain. They are known to participate in cell adhesion as well as cell-surface mediated signalling. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. CD51 encodes integrin alpha chain V. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. The CD61 protein product is the integrin beta chain beta 3. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrin alpha V/beta 3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha V/beta 3 recognizes the sequence R-G-D in a wide array of ligands. The alpha V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase 2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands.
    • Cellular localizationCell Membrane; single-pass type I membrane protein.
    • Database links
    • Alternative names
      • Antigen identified by monoclonal antibody L230 antibody
      • CD51 antibody
      • CD51 antigen antibody
      • CD61 antibody
      • CD61 antigen antibody
      • DKFZp686A08142 antibody
      • GP3A antibody
      • GPIIIa antibody
      • Integrin alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) antibody
      • Integrin alpha v antibody
      • Integrin beta 3 (platelet glycoprotein IIIa, antigen CD61) antibody
      • Integrin beta 3 antibody
      • Integrin beta chain beta 3 antibody
      • ITGAV antibody
      • ITGB3 antibody
      • MSK8 antibody
      • Platelet glycoprotein IIIa antibody
      • Platelet membrane glycoprotein IIIa antibody
      • Vitronectin receptor subunit alpha antibody
      • VNRA antibody
      see all

    References for Anti-CD51 + CD61 antibody [23C6] (ab20143)

    This product has been referenced in:
    • Martino MM  et al. Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability. Biomaterials 30:1089-97 (2009). Read more (PubMed: 19027948) »
    • Scarlett A  et al. Thyroid hormone stimulation of extracellular signal-regulated kinase and cell proliferation in human osteoblast-like cells is initiated at integrin alphaVbeta3. J Endocrinol 196:509-17 (2008). Read more (PubMed: 18310446) »

    See all 6 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"