• Product name
    Anti-CD59 antibody [YTH53.1] (FITC)
    See all CD59 primary antibodies
  • Description
    Rat monoclonal [YTH53.1] to CD59 (FITC)
  • Conjugation
    FITC. Ex: 493nm, Em: 528nm
  • Specificity
    This antibody is specific for CD59.
  • Tested applications
    Suitable for: Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Peripheral Blood T cells.



Our Abpromise guarantee covers the use of ab33150 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt
  • Application notes
    Flow Cyt: 1/1.
    Use 10ul of neat antibody to label 106 cells in 100ul.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
      The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.
    • Involvement in disease
      Defects in CD59 are the cause of CD59 deficiency (CD59D) [MIM:612300].
    • Sequence similarities
      Contains 1 UPAR/Ly6 domain.
    • Post-translational
      N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.
      Glycated. Glycation is found in diabetic subjects, but only at minimal levels in nondiabetic subjects. Glycated CD59 lacks MAC-inhibitory function and confers to vascular complications of diabetes.
    • Cellular localization
      Cell membrane. Secreted. Soluble form found in a number of tissues.
    • Information by UniProt
    • Database links
    • Alternative names
      • 16.3A5 antibody
      • 1F5 antibody
      • 1F5 antigen antibody
      • 20 kDa homologous restriction factor antibody
      • CD 59 antibody
      • CD_antigen=CD59 antibody
      • CD59 antibody
      • CD59 antigen antibody
      • CD59 antigen complement regulatory protein antibody
      • CD59 antigen p18 20 antibody
      • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) antibody
      • CD59 glycoprotein antibody
      • CD59 molecule antibody
      • CD59 molecule complement regulatory protein antibody
      • CD59_HUMAN antibody
      • Cd59a antibody
      • Complement regulatory protein antibody
      • EJ16 antibody
      • EJ30 antibody
      • EL32 antibody
      • FLJ38134 antibody
      • FLJ92039 antibody
      • G344 antibody
      • HRF 20 antibody
      • HRF-20 antibody
      • HRF20 antibody
      • Human leukocyte antigen MIC11 antibody
      • Ly 6 like protein antibody
      • Lymphocytic antigen CD59/MEM43 antibody
      • MAC inhibitory protein antibody
      • MAC IP antibody
      • MAC-inhibitory protein antibody
      • MAC-IP antibody
      • MACIF antibody
      • MACIP antibody
      • MEM43 antibody
      • MEM43 antigen antibody
      • Membrane attack complex (MAC) inhibition factor antibody
      • Membrane attack complex inhibition factor antibody
      • Membrane inhibitor of reactive lysis antibody
      • MGC2354 antibody
      • MIC11 antibody
      • MIN1 antibody
      • MIN2 antibody
      • MIN3 antibody
      • MIRL antibody
      • MSK21 antibody
      • p18 20 antibody
      • Protectin antibody
      • Surface antigen recognized by monoclonal antibody 16.3A5 antibody
      • T cell activating protein antibody
      see all

    References for Anti-CD59 antibody [YTH53.1] (FITC) (ab33150)

    This product has been referenced in:
    • Brasoveanu LI  et al. Melanoma cells constitutively release an anchor-positive soluble form of protectin (sCD59) that retains functional activities in homologous complement-mediated cytotoxicity. J Clin Invest 100:1248-55 (1997). Read more (PubMed: 9276743) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab33150.
    Please use the links above to contact us or submit feedback about this product.


    Sign up