Anti-CD62L antibody [MEL-14] (Biotin) (ab24969)

Overview

  • Product name
    Anti-CD62L antibody [MEL-14] (Biotin)
    See all CD62L primary antibodies
  • Description
    Rat monoclonal [MEL-14] to CD62L (Biotin)
  • Conjugation
    Biotin
  • Specificity
    CD62L/L-selectin
  • Tested applications
    Suitable for: Microcytotoxicity testing, Flow Cyt, IHC-Fr, IP, Blockingmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Tissue/ cell preparation of C3H/eb cloned B lymphoma 38C-13 (Mouse)

  • General notes


    The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.

Properties

Applications

Our Abpromise guarantee covers the use of ab24969 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Microcytotoxicity testing Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.

ab18445-Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

IHC-Fr Use at an assay dependent concentration.
IP Use at an assay dependent concentration.
Blocking Use at an assay dependent concentration.

In vivo and in vitro blocking of adhesion.

Target

  • Function
    Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
  • Tissue specificity
    Expressed in B cell lines and T lymphocytes.
  • Sequence similarities
    Belongs to the selectin/LECAM family.
    Contains 1 C-type lectin domain.
    Contains 1 EGF-like domain.
    Contains 2 Sushi (CCP/SCR) domains.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • A.11 antibody
    • AI528707 antibody
    • CD62 antigen ligand antibody
    • CD62 antigen-like family member L antibody
    • CD62L antibody
    • gp90-MEL antibody
    • IgA nephropathy, susceptibility to, included antibody
    • L Selectin antibody
    • L-selectin antibody
    • LAM-1 antibody
    • LAM1 antibody
    • LECAM1 antibody
    • LEU8 antibody
    • Leukocyte adhesion molecule 1 antibody
    • Leukocyte surface antigen Leu-8 antibody
    • Leukocyte-endothelial cell adhesion molecule 1 antibody
    • Lnhr antibody
    • LSEL antibody
    • Ly-22 antibody
    • Ly-m22 antibody
    • Lyam-1 antibody
    • LYAM1 antibody
    • LYAM1_HUMAN antibody
    • Lymph node homing receptor antibody
    • Lymphocyte adhesion molecule 1 antibody
    • Lymphocyte antigen 22 antibody
    • Lymphocyte surface MEL-14 antigen antibody
    • MEL-14 antibody
    • Pln homing receptor antibody
    • PLNHR antibody
    • Selectin L antibody
    • Selectin, lymphocyte antibody
    • SELL antibody
    • TQ1 antibody
    see all

Anti-CD62L antibody [MEL-14] (Biotin) images

  • Flow cytometry of C57Bl/6 splenocytes labeling CD62L with ab24969 at 0.125µg (solid line), or Rat IgG2a isotype control at 0.125µg (dashed line).

     

References for Anti-CD62L antibody [MEL-14] (Biotin) (ab24969)

ab24969 has not yet been referenced specifically in any publications.

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