Anti-CD62P antibody [Psel.KO.2.12] (ab54426)

Overview

  • Product nameAnti-CD62P antibody [Psel.KO.2.12]
    See all CD62P primary antibodies
  • Description
    Mouse monoclonal [Psel.KO.2.12] to CD62P
  • SpecificityThis antibody recognizes the CD62P cell surface antigen.
  • Tested applicationsIP, IHC-Fr, Flow Cytmore details
  • Species reactivity
    Reacts with: Rat, Sheep, Goat, Human
  • Immunogen

    CD62P transfected 300.19 cells (Human)

  • General notesShelf Life - 18 months, product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.


    Clone Psel.KO.2.12 is reported to inhibit P selectin dependent adhesion between HL60 cells and P selectin transfected COS cells

Properties

Applications

Our Abpromise guarantee covers the use of ab54426 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
IHC-Fr
Flow Cyt
  • Application notesFlow Cyt: 1/50 - 1/100. Use 10µl of the suggested working dilution to label 1x106 cells in 100µl
    IHC-Fr: Use at an assay dependent dilution.
    IP: Use at an assay dependent dilution.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionCa(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
    • Tissue specificityStored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
    • Involvement in diseaseDefects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    • Sequence similaritiesBelongs to the selectin/LECAM family.
      Contains 1 C-type lectin domain.
      Contains 1 EGF-like domain.
      Contains 9 Sushi (CCP/SCR) domains.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • Antigen CD62 antibody
      • CD62 antibody
      • CD62 antigen-like family member P antibody
      • CD62P antibody
      • GMP 140 antibody
      • GMP-140 antibody
      • GMP140 antibody
      • GMRP antibody
      • Granule membrane protein 140 antibody
      • Granulocyte membrane protein antibody
      • GRMP antibody
      • LECAM 3 antibody
      • LECAM3 antibody
      • Leukocyte endothelial cell adhesion molecule 3 antibody
      • Leukocyte-endothelial cell adhesion molecule 3 antibody
      • LYAM3_HUMAN antibody
      • P Selectin antibody
      • P-selectin antibody
      • PADGEM antibody
      • Platelet activation dependent granule-external membrane protein antibody
      • Platelet alpha granule membrane protein antibody
      • PSEL antibody
      • Selectin P (granule membrane protein 140kDa, antigen CD62) antibody
      • SELP antibody
      see all

    References for Anti-CD62P antibody [Psel.KO.2.12] (ab54426)

    ab54426 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry.

    I can confirm that ab18414 can be stored at 4oC as described on the datasheet. This should not be aliquotted and frozen.

    The others I would recommend to aliquot and freeze immediately. Keeping them at 4...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"