Anti-CD62P antibody [Psel.KO.2.5] (ab118522)

Overview

  • Product nameAnti-CD62P antibody [Psel.KO.2.5]
    See all CD62P primary antibodies
  • Description
    Mouse monoclonal [Psel.KO.2.5] to CD62P
  • Tested applicationsSuitable for: IP, IHC-P, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human CD62P transfected 300.19 cells (NP_002996.2).

  • Positive control
    • Human Spleen and Tonsil tissues; Thrombin activated Human platelets.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab118522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Flow Cyt 1/1 - 1/50. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

Target

  • FunctionCa(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.
  • Tissue specificityStored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.
  • Involvement in diseaseDefects in SELP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
  • Sequence similaritiesBelongs to the selectin/LECAM family.
    Contains 1 C-type lectin domain.
    Contains 1 EGF-like domain.
    Contains 9 Sushi (CCP/SCR) domains.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen CD62 antibody
    • CD62 antibody
    • CD62 antigen-like family member P antibody
    • CD62P antibody
    • GMP 140 antibody
    • GMP-140 antibody
    • GMP140 antibody
    • GMRP antibody
    • Granule membrane protein 140 antibody
    • Granulocyte membrane protein antibody
    • GRMP antibody
    • LECAM 3 antibody
    • LECAM3 antibody
    • Leukocyte endothelial cell adhesion molecule 3 antibody
    • Leukocyte-endothelial cell adhesion molecule 3 antibody
    • LYAM3_HUMAN antibody
    • P Selectin antibody
    • P-selectin antibody
    • PADGEM antibody
    • Platelet activation dependent granule-external membrane protein antibody
    • Platelet alpha granule membrane protein antibody
    • PSEL antibody
    • Selectin P (granule membrane protein 140kDa, antigen CD62) antibody
    • SELP antibody
    see all

Anti-CD62P antibody [Psel.KO.2.5] images

  • Immunohistochemical analysis of CD62P expression in Formalin-Fixed, Paraffin-Embedded Human Spleen using 10 µg/ml ab118522 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Immunohistochemical analysis of CD62P expression in Formalin-Fixed, Paraffin-Embedded Human Tonsil using 10 µg/ml ab118522 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • ab118522 at 10µl/106 cells in 100µl staining CD62P in Thrombin activated Human platelets by Flow cytometry.

References for Anti-CD62P antibody [Psel.KO.2.5] (ab118522)

ab118522 has not yet been referenced specifically in any publications.

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