Anti-CD66a + CD66c + CD66d + CD66e antibody [CLB-gran/10] (ab112072)

Overview

  • Product name
    Anti-CD66a + CD66c + CD66d + CD66e antibody [CLB-gran/10]
  • Description
    Mouse monoclonal [CLB-gran/10] to CD66a + CD66c + CD66d + CD66e
  • Specificity
    ab112072 does not cross-react with normal human peripheral B cells, T cells, monocytes and platelets. Weak reactivity has been observed with malignant cells of patients with B cell-derived CLL.
  • Tested applications
    Suitable for: IHC-P, Flow Cyt, WB, IP, ICCmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human granulocytes

  • Positive control
    • Positive tissue: human colon

Properties

Applications

Our Abpromise guarantee covers the use of ab112072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 20 µg/ml.
Flow Cyt Use a concentration of 2 - 8 µg/ml. ab170190-Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.
WB Use at an assay dependent concentration. Predicted molecular weight: CD66a, 57 kDa; CD66c, 38 kDa; CD66d, 27 kDa; CD66e, 77 kDa.
IP Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.

Target

  • Function
    Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.
  • Tissue specificity
    Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. CEA family.
    Contains 7 Ig-like (immunoglobulin-like) domains.
  • Post-translational
    modifications
    Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen CD66 antibody
    • Biliary glycoprotein antibody
    • Carcinoembryonic antigen antibody
    • Carcinoembryonic antigen related cell adhesion molecule 1 antibody
    • Carcinoembryonic antigen related cell adhesion molecule 3 antibody
    • Carcinoembryonic antigen related cell adhesion molecule 5 antibody
    • Carcinoembryonic antigen related cell adhesion molecule 6 antibody
    • Carcinoembryonic antigen-related cell adhesion molecule 5 antibody
    • CD66a antigen antibody
    • CD66d antibody
    • CD66e antibody
    • CD66e antigen antibody
    • CEA antibody
    • CEACAM1 antibody
    • CEACAM3 antibody
    • Ceacam5 antibody
    • CEACAM6 antibody
    • CEAM5_HUMAN antibody
    • Meconium antigen 100 antibody
    see all

References

This product has been referenced in:
  • Teixeira AM  et al. The N-domain of the biliary glycoprotein (BGP) adhesion molecule mediates homotypic binding: domain interactions and epitope analysis of BGPc. Blood 84:211-9 (1994). Read more (PubMed: 7517208) »
  • Tetteroo PA  et al. Neutrophil activation detected by monoclonal antibodies. J Immunol 136:3427-32 (1986). Read more (PubMed: 2937846) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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