Anti-CD84 antibody [CD84.1.21] - Low endotoxin, Azide free (ab119116)

Overview

  • Product nameAnti-CD84 antibody [CD84.1.21] - Low endotoxin, Azide free
    See all CD84 primary antibodies
  • Description
    Mouse monoclonal [CD84.1.21] to CD84 - Low endotoxin, Azide free
  • Tested applicationsSuitable for: IP, Functional Studies, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human CD84-transfected 300.19 cell line.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.40
    Constituent: 99% PBS
    Note: Azide-free PBS
  • Concentration information loading...
  • PurityProtein A purified
  • Purification notesab119116 is purified from cell culture supernatant by protein A affinity chromatography. Purity: is 95% (by SDS-PAGE), 0.2 µm filter sterilized.
  • ClonalityMonoclonal
  • Clone numberCD84.1.21
  • IsotypeIgG2a
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab119116 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration. ab170191-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

Target

  • FunctionPlays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.
  • Tissue specificityPredominantly expressed in hematopoietic tissues, such as lymph node, spleen and peripheral leukocytes. Expressed in macrophages, B-cells, monocytes, platelets, thymocytes, T-cells and dendritic cells. Highly expressed in memory T-cells.
  • Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Developmental stageExpression is slightly increased in naive B-cells after the first dividion. By contrast, expression on memory B-cells decreased with each successive division.
  • DomainITSM (immunoreceptor tyrosine-based switch motif) motif is a cytoplasmic motif which may bind SH2D1A.
  • Post-translational
    modifications
    Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosines phosphorylation of its cytoplasmic domain Phosphorylated on Tyr-296 and Tyr-316 following platelet aggregation.
    N-glycosylated.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD_antigen=CD84 antibody
    • CD84 antibody
    • CD84 antigen antibody
    • CD84 molecule antibody
    • CDw84 antibody
    • Cell surface antigen MAX.3 antibody
    • hCD84 antibody
    • Hly9 beta antibody
    • Hly9-beta antibody
    • Leucocyte differentiation antigen CD84 antibody
    • Leukocyte Antigen antibody
    • Leukocyte antigen CD84 antibody
    • Leukocyte differentiation antigen antibody
    • Leukocyte differentiation antigen CD84 antibody
    • LY9B antibody
    • mCD84 antibody
    • Signaling lymphocytic activation molecule 5 antibody
    • SLAF5_HUMAN antibody
    • SLAM family member 5 antibody
    • SLAMF5 antibody
    see all

References for Anti-CD84 antibody [CD84.1.21] - Low endotoxin, Azide free (ab119116)

ab119116 has not yet been referenced specifically in any publications.

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This antibody does not have blocking function.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"