Anti-CD89 antibody [MIP7c] (ab53357)
Key features and details
- Mouse monoclonal [MIP7c] to CD89
- Suitable for: Inhibition Assay
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-CD89 antibody [MIP7c]
See all CD89 primary antibodies -
Description
Mouse monoclonal [MIP7c] to CD89 -
Host species
Mouse -
Specificity
ab53357 recognises the EC1 domain of the CD89 extracellular region. -
Tested applications
Suitable for: Inhibition Assaymore details -
Species reactivity
Reacts with: Human -
Immunogen
Soluble CD89
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
MIP7c -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab53357 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
Inhibition Assay |
Notes |
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Inhib: Use 4µg for 105 cells.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. -
Tissue specificity
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. -
Sequence similarities
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
Cellular localization
Secreted and Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 2204 Human
- Omim: 147045 Human
- SwissProt: P24071 Human
- Unigene: 659872 Human
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Alternative names
- CD89 antibody
- Fc alpha receptor antibody
- Fc fragment of IgA, receptor for antibody
see all
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab53357 has been referenced in 1 publication.
- Duchemin M et al. IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis. Front Immunol 9:244 (2018). PubMed: 29651286