Anti-CD96 antibody [NK92.39] (ab81717)
Key features and details
- Mouse monoclonal [NK92.39] to CD96
- Suitable for: Blocking, Flow Cyt, Functional Studies
- Reacts with: Human
- Isotype: IgG1
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Overview
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Product name
Anti-CD96 antibody [NK92.39]
See all CD96 primary antibodies -
Description
Mouse monoclonal [NK92.39] to CD96 -
Host species
Mouse -
Tested applications
Suitable for: Blocking, Flow Cyt, Functional Studiesmore details -
Species reactivity
Reacts with: Human -
Immunogen
Tissue, cells or virus corresponding to Human CD96.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
Constituents: PBS, 0.1% BSA -
Concentration information loading...
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Purity
Protein G purified -
Purification notes
ab81717 is 0.2µM filtered. -
Clonality
Monoclonal -
Clone number
NK92.39 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab81717 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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Blocking |
Use at an assay dependent concentration.
ab81717 blocks binding of soluble poliovirus receptor (PVR) to NK92 cells. |
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Flow Cyt |
1/50.
ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use at a starting dilution of 1/50. Optimal dilutions will depend on the detection system used. |
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Functional Studies |
Use at an assay dependent concentration.
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Notes |
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Blocking
Use at an assay dependent concentration. ab81717 blocks binding of soluble poliovirus receptor (PVR) to NK92 cells. |
Flow Cyt
1/50. ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use at a starting dilution of 1/50. Optimal dilutions will depend on the detection system used. |
Functional Studies
Use at an assay dependent concentration. |
Target
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Function
May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. -
Tissue specificity
Expressed on normal T-cell lines and clones, and some transformed T-cells, but no other cultured cell lines tested. It is expressed at very low levels on activated B-cells. -
Involvement in disease
Defects in CD96 are a cause of C syndrome (CSYN) [MIM:211750]; also called Opitz trigonocephaly syndrome. This syndrome is characterized by trigonocephaly and associated anomalies, such as unusual facies, wide alveolar ridges, multiple buccal frenula, limb defects, visceral anomalies, redundant skin, psychomotor retardation and hypotonia. Note=A chromosomal aberration involving CD96 has been found in a patient with C syndrome. Translocation t(3;18)(q13.13;q12.1). CD96 gene was located at the 3q13.13 breakpoint. Precise structural analysis around the breakpoint showed that the gene was disrupted by the translocation in exon 5, probably leading to premature termination or loss of expression of CD96 protein. No gene was detected at the chromosome 18 breakpoint.
Defects in CD96 are a cause of C-like syndrome (CLSYN) [MIM:605039]; also called Opitz trigonocephaly-like syndrome. The C-like syndrome seems to be a severe form of the C syndrome. It is controversial whether there is (1) a gradient of spectrum in the C syndrome, from the mild form (C syndrome) to the severe form (C-like syndrome), or (2) genetic heterogeneity among the patients with the C syndrome. -
Sequence similarities
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 2 Ig-like V-type (immunoglobulin-like) domains. -
Developmental stage
Expressed at low levels on peripheral T-cells and is strongly up-regulated after activation, peaking 6 to 9 days after the activating stimulus. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 10225 Human
- Omim: 606037 Human
- SwissProt: P40200 Human
- Unigene: 142023 Human
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Alternative names
- CD96 antibody
- CD96 molecule antibody
- Cell surface antigen CD96 antibody
see all
Datasheets and documents
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Datasheet download
References (0)
ab81717 has not yet been referenced specifically in any publications.