Overview

  • Product nameAnti-CD97 antibody
    See all CD97 primary antibodies
  • Description
    Rabbit polyclonal to CD97
  • SpecificityImmunogen is 100% homologous in human isoforms a, b, c and d.
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human, Chimpanzee
    Predicted to work with: Monkey
  • Immunogen

    A portion of amino acids 220-270 of human CD97

  • Positive control
    • K562 cell lysate; human spleen tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab72107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 92 kDa (predicted molecular weight: 92 kDa).
IHC-P Use a concentration of 10 µg/ml.

Target

  • FunctionReceptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.
  • Tissue specificityBroadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompagnied by detectable levels of soluble CD97 in the synovial fluid.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
    Contains 5 EGF-like domains.
    Contains 1 GPS domain.
  • DomainThe first two EGF domains mediate the interaction with DAF. A third tandemly arranged EGF domain is necessary for the structural integrity of the binding region.
    Binding to chondroitin sulfate is mediated by the fourth EGF domain.
  • Post-translational
    modifications
    Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Cellular localizationCell membrane and Secreted > extracellular space.
  • Information by UniProt
  • Database links
  • Alternative names
    • ADGRE5 antibody
    • Adhesion G protein-coupled receptor E5 antibody
    • CD 97 antibody
    • CD_antigen=CD97 antibody
    • CD97 antibody
    • CD97 antigen antibody
    • CD97 antigen subunit beta antibody
    • CD97 molecule antibody
    • CD97_HUMAN antibody
    • Leukocyte antigen CD97 antibody
    • Seven span transmembrane protein antibody
    • Seven transmembrane helix receptor antibody
    • Seven transmembrane heterodimeric receptor associated with inflammation antibody
    • TM7LN 1 antibody
    • TM7LN1 antibody
    see all

Anti-CD97 antibody images

  • All lanes : Anti-CD97 antibody (ab72107) at 2 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate with immunizing peptide


    Predicted band size : 92 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)
  • Analysis of CD97 expression in human spleen tissue using ab72107 at 10ug/ml.

References for Anti-CD97 antibody (ab72107)

ab72107 has not yet been referenced specifically in any publications.

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