Overview

  • Product nameAnti-Cdc14B antibody
    See all Cdc14B primary antibodies
  • Description
    Rabbit polyclonal to Cdc14B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human Cdc14B (ENSP00000265659, amino acids 1-471).

  • Positive control
    • Human liver tissue lysate; Cdc14B transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab104415 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: Isoform 2, 57 ; Isoform 3, 54 kDa.

Target

  • FunctionDual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.
  • DomainComposed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.
  • Cellular localizationNucleus > nucleolus. Nucleus > nucleoplasm. Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
  • Information by UniProt
  • Database links
  • Alternative names
    • CC14B_HUMAN antibody
    • Cdc 14B antibody
    • Cdc 14B1 antibody
    • Cdc 14B2 antibody
    • CDC 14B3 antibody
    • CDC14 cell division cycle 14 homolog B antibody
    • CDC14 homolog B antibody
    • Cdc14b antibody
    • Cdc14B1 antibody
    • Cdc14B2 antibody
    • CDC14B3 antibody
    • Cell division cycle 14 homolog B antibody
    • Dual specificity protein phosphatase CDC14B antibody
    • hCDC 14B antibody
    • hCDC14B antibody
    • OTTHUMP00000063774 antibody
    see all

Anti-Cdc14B antibody images

  • Anti-Cdc14B antibody (ab104415) at 1 µg/ml + Human liver tissue lysate at 50 µg

    Predicted band size : Isoform 2, 57 ; Isoform 3, 54 kDa
  • All lanes : Anti-Cdc14B antibody (ab104415) at 1 µg/ml

    Lane 1 : Cdc14B transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : Isoform 2, 57 ; Isoform 3, 54 kDa

References for Anti-Cdc14B antibody (ab104415)

ab104415 has not yet been referenced specifically in any publications.

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