FunctionFunctions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDK1 and activate its kinase activity.
Sequence similaritiesBelongs to the MPI phosphatase family. Contains 1 rhodanese domain.
Developmental stageExpressed predominantly in G2 phase.
Post-translational modificationsPhosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4.
ab62191 at a dilution of 1/50 staining paraffin embedded human colon carcinoma tissue section by immunohistochemistry. Samples were untreated (left hand panel) or treated (right hand panel) with the immunizing peptide.
References for Anti-Cdc25C (phospho T48) antibody (ab62191)
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