Overview

  • Product name
  • Description
    Rabbit polyclonal to CDC2L5
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal amino acids 281-310 of Mouse CDC2L5.

  • Positive control
    • Mouse testis tissue lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab124101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 165 kDa.

Target

  • Function
    Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
  • Tissue specificity
    Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus speckle.
  • Information by UniProt
  • Database links
  • Alternative names
    • CDC2 related protein kinase 5 antibody
    • CDC2-related protein kinase 5 antibody
    • CDC2L antibody
    • CDK13 antibody
    • CDK13_HUMAN antibody
    • cell division controller cholinesterase related antibody
    • cell division cycle 2 like 5 (cholinesterase related cell division controller) antibody
    • cell division cycle 2 like 5 antibody
    • Cell division cycle 2 like protein kinase 5 antibody
    • Cell division cycle 2-like protein kinase 5 antibody
    • Cell division protein kinase 13 antibody
    • CHED antibody
    • Cholinesterase related cell division controller antibody
    • Cholinesterase-related cell division controller antibody
    • cyclin dependent kinase 13 antibody
    • Cyclin-dependent kinase 13 antibody
    • hCDK13 antibody
    see all

Images

  • Anti-CDC2L5 antibody (ab124101) at 1/100 dilution + Mouse testis tissue lysate at 35 µg

    Predicted band size : 165 kDa

References

ab124101 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab124101.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up