Anti-Cdc4 / Fbw7 / hSel 10 antibody (ab55036)

Overview

  • Product nameAnti-Cdc4 / Fbw7 / hSel 10 antibody
    See all Cdc4 / Fbw7 / hSel 10 primary antibodies
  • Description
    Mouse monoclonal to Cdc4 / Fbw7 / hSel 10
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human, Recombinant Fragment
  • Immunogen

    Recombinant fragment, corresponding to amino acids 599-708 of Human Cdc4/ Fbw7/ hSel 10

Properties

Applications

Our Abpromise guarantee covers the use of ab55036 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 3 µg/ml.
WB Use a concentration of 1 - 5 µg/ml. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

Target

  • RelevanceFbw7 is a member of the F box protein family which are characterized by an approximately 40 amino acid motif, the F box. The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F box), which function in phosphorylation-dependent ubiquitination. The F box proteins are divided into 3 classes: Fbws containing WD40 domains, Fbls containing leucine rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. Fbw7 belongs to the Fbws class; in addition to an F box, this protein contains 7 tandem WD40 repeats. It binds directly to cyclin E and probably targets cyclin E for ubiquitin mediated degradation. Mutations of this gene are detected in ovarian and breast cancer cell lines. Alternative splicing of this gene generates 2 transcript variants diverging at the 5' termini.
  • Cellular localizationCytoplasmic and Nuclear
  • Database links
  • Alternative names
    • AGO antibody
    • Archipelago Drosophila homolog of antibody
    • Archipelago homolog antibody
    • CDC 4 antibody
    • CDC4 antibody
    • DKFZp686F23254 antibody
    • F box and WD 40 domain protein 7 antibody
    • F box protein FBW7 antibody
    • F box protein FBX30 antibody
    • F box protein SEL 10 antibody
    • F box/WD repeat protein 7 antibody
    • FBW 7 antibody
    • FBW6 antibody
    • FBW7 antibody
    • FBX 30 antibody
    • FBXO30 antibody
    • FBXW 6 antibody
    • FBXW 7 antibody
    • FBXW7 antibody
    • hAgo antibody
    • hCdc4 antibody
    • Homolog of C elegans sel 10 antibody
    • SEL10 antibody
    see all

Anti-Cdc4 / Fbw7 / hSel 10 antibody images

  • Cdc4 / Fbw7 / hSel 10 antibody (ab55036) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human lung.
  • Western blot against tagged recombinant protein immunogen using ab55036 Cdc4 / Fbw7 / hSel 10 antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

References for Anti-Cdc4 / Fbw7 / hSel 10 antibody (ab55036)

ab55036 has not yet been referenced specifically in any publications.

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