Overview

  • Product nameAnti-CDC42 antibody
    See all CDC42 primary antibodies
  • Description
    Rabbit polyclonal to CDC42
  • Specificityab28149 recognises CDC42.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Cow, Human
  • Immunogen

    Synthetic peptide:

    TAEKLARDLKAVKY

    with a residue C added to it and conjugated to KLH, corresponding to amino acids 141/154 of Human CDC42

  • Positive control
    • Mouse Brain Tissue Extract, Rat Brain Tissue Extract.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab28149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: 1/1000 using ECL detection. Predicted molecular weight: 24 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Causes the formation of thin, actin-rich surface projections called filopodia.
    • Sequence similaritiesBelongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
    • Post-translational
      modifications
      AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
    • Cellular localizationCell membrane.
    • Information by UniProt
    • Database links
    • FormThere are 2 isoforms produced by alternative splicing. Isoform 1 also known as: Brain; Isoform 2 also known as: Placental.
    • Alternative names
      • CDC42 antibody
      • CDC42_HUMAN antibody
      • CDC42Hs antibody
      • Cell division control protein 42 homolog antibody
      • Cell division cycle 42 (GTP binding protein 25kDa) antibody
      • Cell division cycle 42 antibody
      • dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)) antibody
      • dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)) antibody
      • G25K antibody
      • G25K GTP-binding protein antibody
      • Growth regulating protein antibody
      • GTP binding protein 25kDa antibody
      • Small GTP binding protein CDC42 antibody
      • TKS antibody
      see all

    References for Anti-CDC42 antibody (ab28149)

    ab28149 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"