Anti-CDC42 binding protein kinase alpha antibody (ab95886)

Overview

  • Product name
    Anti-CDC42 binding protein kinase alpha antibody
    See all CDC42 binding protein kinase alpha primary antibodies
  • Description
    Rabbit polyclonal to CDC42 binding protein kinase alpha
  • Tested applications
    Suitable for: IPmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Rhesus monkey, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region between residues 1610 and 1660 of Human CDC42 binding protein kinase alpha (CAH71185.1).

  • Positive control
    • HeLa whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab95886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at 2-5 µg/mg of lysate.
  • Application notes
    Is unsuitable for WB.
  • Target

    • Function
      May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation.
    • Tissue specificity
      Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
    • Sequence similarities
      Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 1 CNH domain.
      Contains 1 CRIB domain.
      Contains 1 PH domain.
      Contains 1 phorbol-ester/DAG-type zinc finger.
      Contains 1 protein kinase domain.
    • Cellular localization
      Cytoplasm. Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent.
    • Information by UniProt
    • Database links
    • Alternative names
      • A930014J19Rik antibody
      • CDC42 binding protein kinase alpha (DMPK like) antibody
      • CDC42 binding protein kinase alpha antibody
      • CDC42 binding protein kinase alpha dmpk like antibody
      • CDC42 binding protein kinase beta antibody
      • CDC42-binding protein kinase alpha antibody
      • CDC42BPA antibody
      • DKFZp686L1738 antibody
      • DKFZp686P1738 antibody
      • DMPK like antibody
      • DMPK-like alpha antibody
      • FLJ23347 antibody
      • KIAA0451 antibody
      • MGC189823 antibody
      • MRCK alpha antibody
      • mrck antibody
      • mrcka antibody
      • MRCKA_HUMAN antibody
      • Myotonic dystrophy kinase related CDC42 binding protein kinase alpha antibody
      • Myotonic dystrophy kinase-related CDC42-binding kinase alpha antibody
      • Myotonic dystrophy protein kinase-like alpha antibody
      • OTTHUMP00000035727 antibody
      • OTTHUMP00000035728 antibody
      • OTTHUMP00000035729 antibody
      • OTTHUMP00000035730 antibody
      • pk428 antibody
      • RP5-1087E8.4 antibody
      • Ser thr protein kinase PK428 antibody
      • Ser thr protein kinase related to the myotonic dystrophy protein kinase antibody
      • Serine/threonine protein kinase MRCK alpha antibody
      • Serine/threonine-protein kinase MRCK alpha antibody
      see all

    Images

    • Detection of CDC42 binding protein kinase alpha by Western Blot of Immunprecipitate.
      An other antibody at 1µg/ml staining CDC42 binding protein kinase alpha in HeLa whole cell lysate immunoprecipitated using ab95886 at 3µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 10 seconds.

    References

    ab95886 has not yet been referenced specifically in any publications.

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