Overview

  • Product name
    Anti-Cdk5 antibody - C-terminal
    See all Cdk5 primary antibodies
  • Description
    Rabbit polyclonal to Cdk5 - C-terminal
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Cow
  • Immunogen

    Synthetic peptide, corresponding to a region within C terminal amino acids 229-292 of Human Cdk5.

  • Positive control
    • HeLa and Mouse brain whole cell lysates; A549 cells; A431 and H1299 cell lines; Human ES2 xenograft tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab151233 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 33 kDa.
IHC-P 1/100 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol using 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0).
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.
  • Sequence similarities
    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization
    Cytoplasm. Cell projection > lamellipodium. Cell projection > growth cone. In axonal growth cone with extension to the peripheral lamellipodia.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cdk 5 antibody
    • Cdk5 antibody
    • CDK5_HUMAN antibody
    • Cell division protein kinase 5 antibody
    • Crk6 antibody
    • Cyclin dependent kinase 5 antibody
    • Cyclin-dependent kinase 5 antibody
    • Protein kinase CDK5 splicing antibody
    • PSSALRE antibody
    • Serine threonine protein kinase PSSALRE antibody
    • Serine/threonine-protein kinase PSSALRE antibody
    • Tau protein kinase II catalytic subunit antibody
    • TPKII catalytic subunit antibody
    see all

Images

  • Anti-Cdk5 antibody - C-terminal (ab151233) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size : 33 kDa
  • Anti-Cdk5 antibody - C-terminal (ab151233) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

    Predicted band size : 33 kDa
  • Immunofluorescent analysis of paraformaldehyde-fixed A549 cells labeling Cdk5 with ab151233 at 1/200 dilution.
  • Immunohistochemical analysis of paraffin-embedded ES2 xenograft labeling Cdk5 with ab151233 at 1/100 dilution.

References

ab151233 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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