The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Detects a band of approximately 116 kDa (predicted molecular weight: 116 kDa).
1/10 - 1/50.
FunctionMediates phosphorylation of MECP2.
Tissue specificityExpressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.
Involvement in diseaseNote=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15). Defects in CDKL5 are a cause of epileptic encephalopathy early infantile type 2 (EIEE2) [MIM:300672]; also known as atypical CDKL5-related Rett syndrome. EIEE2 is a severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements.
Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
ab71697, at 1/10 dilution, staining CDKL5 in human lung carcinoma by Immunohistochemistry using formalin fixed, paraffin embedded tissue. ab71697 was peroxidase conjugated to the secondary antibody, followed by DAB staining.
References for Anti-CDKL5 antibody - C-terminal (ab71697)
has not yet been referenced specifically in any publications.
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