Overview

  • Product nameAnti-CDKL5 antibody - C-terminal
    See all CDKL5 primary antibodies
  • Description
    Rabbit polyclonal to CDKL5 - C-terminal
  • Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide from the C terminal region of human CDKL5 conjugated to KLH.

  • Positive control
    • Mouse lung tissue lysate. Human lung carcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab71697 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 116 kDa (predicted molecular weight: 116 kDa).
IHC-P 1/10 - 1/50.

Target

  • FunctionMediates phosphorylation of MECP2.
  • Tissue specificityExpressed in brain, lung, kidney, prostate, ovary, placenta, pancreas and testis.
  • Involvement in diseaseNote=Chromosomal aberrations involving CDKL5 are found in patients manifesting early-onset seizures and spams and psychomotor impairment. Translocation t(X;6)(p22.3;q14); translocation t(X;7)(p22.3;p15).
    Defects in CDKL5 are a cause of epileptic encephalopathy early infantile type 2 (EIEE2) [MIM:300672]; also known as atypical CDKL5-related Rett syndrome. EIEE2 is a severe form of epilepsy characterized by seizures or spasms beginning in infancy. Patients manifest features resembling Rett syndrome such as microcephaly, lack of speech development, stereotypic hand movements.
  • Sequence similaritiesBelongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Autophosphorylated.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cdkl5 antibody
    • CDKL5_HUMAN antibody
    • Cyclin dependent kinase 5 transcript antibody
    • Cyclin-dependent kinase-like 5 antibody
    • EIEE2 antibody
    • ISSX antibody
    • Serine/threonine kinase 9 antibody
    • Serine/threonine-protein kinase 9 antibody
    • Stk9 antibody
    see all

Anti-CDKL5 antibody - C-terminal images

  • Anti-CDKL5 antibody - C-terminal (ab71697) at 1/100 dilution + mouse lung tissue lysate at 12.5 µg

    Predicted band size : 116 kDa
    Observed band size : 116 kDa
    Additional bands at : 70 kDa. We are unsure as to the identity of these extra bands.
  • ab71697, at 1/10 dilution, staining CDKL5 in human lung carcinoma by Immunohistochemistry using formalin fixed, paraffin embedded tissue. ab71697 was peroxidase conjugated to the secondary antibody, followed by DAB staining.

References for Anti-CDKL5 antibody - C-terminal (ab71697)

ab71697 has not yet been referenced specifically in any publications.

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