Human Predicted to work with:
Mouse, Rat, Pig, Orangutan
Recombinant fragment: MLELRHRGSC PGPREAVSPP HREGEAAGGD HETESTSDKE TDIDDRYGDL DSRTDSDIPE IPPSSDRTPE ILKKALSGLS SRWKNWWIRG ILTLTMIS, corresponding to amino acids 1-99 of Human CDS1 (NP_001254) with a 26 kDa tag
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa.
Use at an assay dependent dilution.
FunctionProvides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells.
Tissue specificityExpressed in adult tissues such as placenta, brain, small intestine, ovary, testis and prostate. Highly expressed in fetal kidney, lung and brain. Lower level in fetal liver.
PathwayPhospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Sequence similaritiesBelongs to the CDS family.
Cellular localizationEndoplasmic reticulum membrane. Cytoplasmic aspect of the endoplasmic reticulum.