Anti-CEACAM3 antibody (ab111736)
Key features and details
- Rabbit polyclonal to CEACAM3
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-CEACAM3 antibody
See all CEACAM3 primary antibodies -
Description
Rabbit polyclonal to CEACAM3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 55 and 241 of Human CEACAM3 (UniProt ID: P40198).
-
Positive control
- A431 whole cell lysate
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab111736 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
1/500 - 1/3000. Predicted molecular weight: 27 kDa.
|
Notes |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 27 kDa. |
Target
-
Function
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. -
Tissue specificity
CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney. -
Sequence similarities
Belongs to the immunoglobulin superfamily. CEA family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
Domain
The cytosolic domain is involved in S100A9 interaction. -
Post-translational
modificationsTyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. -
Cellular localization
Membrane. - Information by UniProt
-
Database links
- Entrez Gene: 1084 Human
- Omim: 609142 Human
- SwissProt: P40198 Human
- Unigene: 11 Human
-
Alternative names
- carcinoembryonic antibody
- Carcinoembryonic antigen CGM1 antibody
- Carcinoembryonic antigen gene family member 1 antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (0)
ab111736 has not yet been referenced specifically in any publications.