Overview

  • Product name
  • Description
    Rabbit polyclonal to CEACAM3
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 55 and 241 of Human CEACAM3 (UniProt ID: P40198).

  • Positive control
    • A431 whole cell lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111736 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 27 kDa.

Target

  • Function
    Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.
  • Tissue specificity
    CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. CEA family.
    Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Domain
    The cytosolic domain is involved in S100A9 interaction.
  • Post-translational
    modifications
    Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • carcinoembryonic antibody
    • Carcinoembryonic antigen CGM1 antibody
    • Carcinoembryonic antigen gene family member 1 antibody
    • carcinoembryonic antigen related cell adhesion molecule 3 antibody
    • Carcinoembryonic antigen-related cell adhesion molecule 3 antibody
    • cd66 d antibody
    • CD66d antibody
    • CD66d antigen antibody
    • CEA antibody
    • CEACAM 3 antibody
    • CEACAM-3 antibody
    • Ceacam3 antibody
    • CEAM 3 antibody
    • CEAM-3 antibody
    • CEAM3 antibody
    • CEAM3_HUMAN antibody
    • CGM1 antibody
    • Nonspecific cross reacting antigen antibody
    • W264 antibody
    • W282 antibody
    see all

Images

  • Anti-CEACAM3 antibody (ab111736) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 27 kDa

References

ab111736 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab111736.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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