FunctionMay function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Tissue specificityWidely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
Sequence similaritiesBelongs to the ced-6 family. Contains 1 PID domain.
Cellular localizationCytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes.