Overview

  • Product name
  • Description
    Rabbit polyclonal to CED6
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide, corresponding to a sequence within amino acids 241-304 of Human CED6 (NP_057399).

  • Positive control
    • 293T, HeLa, HepG2, MOLT4 or NIH3T3 cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab97669 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.

Target

  • Function
    May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
  • Tissue specificity
    Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.
  • Sequence similarities
    Belongs to the ced-6 family.
    Contains 1 PID domain.
  • Cellular localization
    Cytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes.
  • Information by UniProt
  • Database links
  • Alternative names
    • CED6 antibody
    • Cell death protein 6 homolog antibody
    • Engulfment adapter protein antibody
    • Engulfment adaptor PTB domain containing 1 antibody
    • GULP antibody
    • GULP, engulfment adaptor PTB domain containing 1 antibody
    • GULP1 antibody
    • GULP1_HUMAN antibody
    • Protein GULP antibody
    • PTB domain adapter protein CED 6 antibody
    • PTB domain adapter protein CED-6 antibody
    • PTB domain adaptor protein CED6 antibody
    • PTB domain-containing engulfment adapter protein 1 antibody
    see all

Images

  • All lanes : Anti-CED6 antibody (ab97669) at 1/1000 dilution

    Lane 1 : HepG2 whole cell lysate
    Lane 2 : MOLT4 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 35 kDa
  • Anti-CED6 antibody (ab97669) at 1/1000 dilution + NIH3T3 whole cell lysate at 30 µg

    Predicted band size : 35 kDa

References

This product has been referenced in:
  • Sullivan CS  et al. The adaptor protein GULP promotes Jedi-1-mediated phagocytosis through a clathrin-dependent mechanism. Mol Biol Cell 25:1925-36 (2014). Read more (PubMed: 24743597) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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