• Product name
    Anti-Cellular Apoptosis Susceptibility antibody
    See all Cellular Apoptosis Susceptibility primary antibodies
  • Description
    Rabbit polyclonal to Cellular Apoptosis Susceptibility
  • Host species
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide from N terminus of human Cellular Apoptosis Susceptibility.

  • Positive control
    • Human Liver carcinoma, HeLa cells and NIH 3T3 cells.



Our Abpromise guarantee covers the use of ab27518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IHC-P: 1/100 for 10 min at room temperature. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min and then cool at room temperature for 20 min.
    WB: Use at a concentration of 0.5 - 2 µg/ml for 2 hours at room temperature. Predicted molecular weight: 110 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
    • Tissue specificity
      Highly expressed in proliferating cells.
    • Sequence similarities
      Belongs to the XPO2/CSE1 family.
      Contains 1 importin N-terminal domain.
    • Cellular localization
      Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAS antibody
      • Cellular apoptosis susceptibility protein antibody
      • Chromosome segregation 1 (yeast homolog) like antibody
      • Chromosome segregation 1 Like antibody
      • Chromosome segregation 1 like protein antibody
      • Chromosome segregation 1-like protein antibody
      • Chromosome segregation gene CSE1 antibody
      • CSE 1 antibody
      • CSE 1 chromosome segregation 1 like antibody
      • CSE 1 chromosome segregation 1 like protein antibody
      • CSE 1L antibody
      • CSE1 antibody
      • CSE1 chromosome segregation 1 like (yeast) antibody
      • CSE1 chromosome segregation 1 like antibody
      • CSE1 chromosome segregation 1 like protein antibody
      • CSE1L antibody
      • Exp 2 antibody
      • Exp2 antibody
      • Exportin 2 antibody
      • Exportin-2 antibody
      • Exportin2 antibody
      • Importin alpha re exporter antibody
      • Importin-alpha re-exporter antibody
      • MGC117283 antibody
      • MGC130036 antibody
      • MGC130037 antibody
      • XPO 2 antibody
      • XPO2 antibody
      • XPO2_HUMAN antibody
      see all


    • Ab27518, at a dilution of 1/100, staining Cellular Apoptosis Susceptibility protein in formalin fixed paraffin embedded human liver carcinoma tissue section by Immunohistochemistry.


    This product has been referenced in:
    • Pupure J  et al. Neuroprotective properties of mildronate, a mitochondria-targeted small molecule. Neurosci Lett 470:100-5 (2010). WB, IHC-P ; Mouse . Read more (PubMed: 20036318) »
    • Wang Y  et al. Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Mol Cell Proteomics 8:585-95 (2009). Read more (PubMed: 19001410) »

    See all 2 Publications for this product

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