Anti-Cellular Apoptosis Susceptibility antibody, prediluted (ab27519)

Overview

  • Product nameAnti-Cellular Apoptosis Susceptibility antibody, prediluted
    See all Cellular Apoptosis Susceptibility primary antibodies
  • Description
    Rabbit polyclonal to Cellular Apoptosis Susceptibility, prediluted
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    A synthetic peptide from N terminaus of human Cellular Apoptosis Susceptibility.

  • Positive control
    • Hela, NIH/3T3 and human liver carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab27519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: Ready to use for 10 minutes at room temperature. Staining of formalin fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 minutes followed by cooling at room temperature for 20 minutes.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionExport receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
    • Tissue specificityHighly expressed in proliferating cells.
    • Sequence similaritiesBelongs to the XPO2/CSE1 family.
      Contains 1 importin N-terminal domain.
    • Cellular localizationCytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • CAS antibody
      • Cellular apoptosis susceptibility protein antibody
      • Chromosome segregation 1 (yeast homolog) like antibody
      • Chromosome segregation 1 Like antibody
      • Chromosome segregation 1 like protein antibody
      • Chromosome segregation 1-like protein antibody
      • Chromosome segregation gene CSE1 antibody
      • CSE 1 antibody
      • CSE 1 chromosome segregation 1 like antibody
      • CSE 1 chromosome segregation 1 like protein antibody
      • CSE 1L antibody
      • CSE1 antibody
      • CSE1 chromosome segregation 1 like (yeast) antibody
      • CSE1 chromosome segregation 1 like antibody
      • CSE1 chromosome segregation 1 like protein antibody
      • CSE1L antibody
      • Exp 2 antibody
      • Exp2 antibody
      • Exportin 2 antibody
      • Exportin-2 antibody
      • Exportin2 antibody
      • Importin alpha re exporter antibody
      • Importin-alpha re-exporter antibody
      • MGC117283 antibody
      • MGC130036 antibody
      • MGC130037 antibody
      • XPO 2 antibody
      • XPO2 antibody
      • XPO2_HUMAN antibody
      see all

    Anti-Cellular Apoptosis Susceptibility antibody, prediluted images

    • Ab27519, prediluted, staining Cellular Apoptosis Susceptibility in formalin fixed paraffin embedded sections by Immunohistochemistry.

    References for Anti-Cellular Apoptosis Susceptibility antibody, prediluted (ab27519)

    ab27519 has not yet been referenced specifically in any publications.

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