Anti-CELSR1 antibody - Extracellular domain (ab188912)

Overview

  • Product name
    Anti-CELSR1 antibody - Extracellular domain
    See all CELSR1 primary antibodies
  • Description
    Rabbit polyclonal to CELSR1 - Extracellular domain
  • Specificity
    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Monkey
  • Immunogen

    Synthetic peptide corresponding to Human CELSR1 (N terminal). 20 amino acid peptide from the extracellular domain. NP_055061.1.
    Database link: Q9NYQ6

  • Positive control
    • Human brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab188912 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 8 - 15 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Relevance
    CELSR1 is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor like repeats and two laminin A G type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact mediated communication, with cadherin domains acting as homophilic binding regions and the EGF like domains involved in cell adhesion and receptor ligand interactions. This particular member is a developmentally regulated, neural specific gene which plays an unspecified role in early embryogenesis.ESTs have been isolated from B-cell/lung/testis, breast, brain, colon, embryo, head/neck, heart, heart/melanocyte/uterus, kidney, lung, lymph node, placenta, and tonsil libraries.
  • Cellular localization
    Integral membrane protein
  • Database links
  • Alternative names
    • Cadherin EGF LAG seven pass G type receptor antibody
    • Cadherin EGF LAG seven pass G type receptor 1 antibody
    • CDHF 9 antibody
    • CDHF9 antibody
    • CELS R1 antibody
    • CELSR 1 antibody
    • DKFZp434P0729 antibody
    • Flamingo homolog 2 antibody
    • Flamingo homolog antibody
    • Flamingo homolog Drosophila antibody
    • FMI 2 antibody
    • FMI2 antibody
    • HFMI 2 antibody
    • HFMI2 antibody
    • ME 2 antibody
    • ME2 antibody
    • OTTHUMP00000028852 antibody
    • Protocadherin flamingo 2 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain tissue labeling CELSR1 with ab188912 at 15µg/ml.

References

ab188912 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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