Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SequenceHASSGKDVPECKTQ

Specifications

Our Abpromise guarantee covers the use of ab45476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • CENP E
    • Centromere associated protein E
    • Centromere autoantigen E
    • Centromere autoantigen E (312kD)
    • Centromere protein E
    • Centromere protein E 312kDa
    • KIF10
    • Kinesin family member 10
    • Kinesin related protein
    • Kinesin related protein CENPE
    • PPP1R61
    • Protein phosphatase 1, regulatory subunit 61
    see all
  • RelevanceCENPE is a 250-300 kDa human centromere-associated kinesin-like motor protein that accumulates in G2 phase. In contrast to other centromere proteins, CENPE is not detected at centromeres during interphase, and first appears at the centromere region of chromosomes during prometaphase. CENPE function is required for the transition from metaphase to anaphase. CENPE is probably one of the motors responsible for mammalian chromosome movement and/or spindle elongation.
  • Cellular localizationAssociates with kinetochores during congression, relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division.

References for CENPE peptide (ab45476)

ab45476 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"