The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Centromere associated protein E
Centromere autoantigen E
Centromere autoantigen E (312kD)
Centromere protein E
Centromere protein E 312kDa
Kinesin family member 10
Kinesin related protein
Kinesin related protein CENPE
Protein phosphatase 1, regulatory subunit 61
RelevanceCENPE is a 250-300 kDa human centromere-associated kinesin-like motor protein that accumulates in G2 phase. In contrast to other centromere proteins, CENPE is not detected at centromeres during interphase, and first appears at the centromere region of chromosomes during prometaphase. CENPE function is required for the transition from metaphase to anaphase. CENPE is probably one of the motors responsible for mammalian chromosome movement and/or spindle elongation.
Cellular localizationAssociates with kinetochores during congression, relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division.
References for CENPE peptide (ab45476)
has not yet been referenced specifically in any publications.
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