Overview

  • Product nameAnti-CENPJ antibody
    See all CENPJ primary antibodies
  • Description
    Mouse monoclonal to CENPJ
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 979-1089 of Human CENPJ

Properties

Applications

Our Abpromise guarantee covers the use of ab57659 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionPlays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome.
    • Involvement in diseaseDefects in CENPJ are the cause of microcephaly primary type 6 (MCPH6) [MIM:608393]. A disorder defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits.
      Defects in CENPJ are the cause of Seckel syndrome type 4 (SCKL4) [MIM:613676]. SCKL4 is a rare autosomal recessive disorder characterized by proportionate dwarfism of prenatal onset associated with low birth weight, growth retardation, severe microcephaly with a bird-headed like appearance, and mental retardation.
    • Sequence similaritiesBelongs to the TCP10 family.
    • Post-translational
      modifications
      Phosphorylation at Ser-589 and Ser-595 by PLK2 is required for procentriole formation and centriole elongation. Phosphorylation by PLK2 oscillates during the cell cycle: it increases at G1/S transition and decreases during the exit from mitosis. Phosphorylation at Ser-595 is also mediated by PLK4 but is not a critical step in PLK4 function in procentriole assembly.
    • Cellular localizationCytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > centrosome > centriole. Localized within the center of microtubule asters. During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.
    • Information by UniProt
    • Database links
    • Alternative names
      • CENP-J antibody
      • CENPJ antibody
      • CENPJ_HUMAN antibody
      • Centromere protein J antibody
      • Centrosomal P4.1-associated protein antibody
      • CPAP antibody
      • LAG-3-associated protein antibody
      • LAP antibody
      • LIP1 antibody
      • LYST-interacting protein 1 antibody
      • MCPH6 antibody
      see all

    Anti-CENPJ antibody images

    • Western blot against tagged recombinant protein immunogen using ab57659 CENPJ antibody at 1ug/ml. Predicted band size of immunogen is 38 kDa

    References for Anti-CENPJ antibody (ab57659)

    ab57659 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"