Synthetic phosphopeptide derived from Human CENTB1 around the phosphorylation site of serine 554 (P-G-SP-L-R).
Human lung carcinoma tissue.
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage bufferpH: 7.40 Preservative: 0.02% Sodium azide Constituents: 49.1% PBS, 0.88% Sodium chloride, 50% Glycerol Note: without Mg2+ and Ca2+
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PurityImmunogen affinity purified
Purification notesab111378 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
DomainPH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.
Post-translational modificationsPhosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.