Overview

  • Product name
    Anti-Ceruloplasmin antibody
    See all Ceruloplasmin primary antibodies
  • Description
    Goat polyclonal to Ceruloplasmin
  • Specificity
    By immunoelectrophoresis and ELISA this antibody reacts specifically with ceruloplasmin. No antibody was detected against other serum proteins.
  • Tested applications
    Suitable for: WB, ELISA, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Unfortunately, this information is considered to be commercially sensitive

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab19171 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 122 kDa.
ELISA 1/100 - 1/1000.
ICC 1/200 - 1/2000.

Target

  • Function
    Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane.
  • Tissue specificity
    Expressed by the liver and secreted in plasma.
  • Involvement in disease
    Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
    Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.
  • Sequence similarities
    Belongs to the multicopper oxidase family.
    Contains 3 F5/8 type A domains.
    Contains 6 plastocyanin-like domains.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • CERU_HUMAN antibody
    • Ceruloplasmin antibody
    • CP 2 antibody
    • CP antibody
    • CP2 antibody
    • Ferroxidase antibody
    see all

References for Anti-Ceruloplasmin antibody (ab19171)

This product has been referenced in:
  • Wisniewska M  et al. Copper to Zinc Ratio as Disease Biomarker in Neonates with Early-Onset Congenital Infections. Nutrients 9:N/A (2017). WB ; Human . Read more (PubMed: 28358335) »
  • Hatori Y  et al. Functional partnership of the copper export machinery and glutathione balance in human cells. J Biol Chem 287:26678-87 (2012). WB ; Mouse . Read more (PubMed: 22648419) »

See all 4 Publications for this product

Product Wall

Thank you for your patience. I am afraid that the originator of the product can only confirm that the antibody was made with the whole protein and not a synthesized peptide, and that the goat was immunized with native protein ceruloplasmin. I am ...

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Thank you for your enquiry. Ab8749 is a polyclonal antibody raised to the full length protein, and will therefore consist of a mixed population of IgGs, each of which will recognise a different epitope. The immunogen for Ab19171 is considered c...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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