Overview

  • Product name
  • Description
    Rabbit polyclonal to CES2
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 343-373 of Human CES2 (NP_003860).

  • Positive control
    • Human hepatocarcinoma tissue; MCF7 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab111751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 62 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.
  • Tissue specificity
    Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
  • Sequence similarities
    Belongs to the type-B carboxylesterase/lipase family.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Endoplasmic reticulum lumen.
  • Information by UniProt
  • Database links
  • Alternative names
    • Carboxylesterase 2 (intestine, liver) antibody
    • Carboxylesterase 2 antibody
    • CE-2 antibody
    • CES2 antibody
    • CES2A1 antibody
    • Cocaine esterase antibody
    • EC 3.1.1.1 antibody
    • EST2_HUMAN antibody
    • hCE-2 antibody
    • ICE antibody
    • Iintestinal carboxylesterase liver carboxylesterase 2 antibody
    • Intestinal carboxylesterase; liver carboxylesterase-2 antibody
    • Methylumbelliferyl acetate deacetylase 2 antibody
    • PCE 2 antibody
    • PCE-2 antibody
    see all

Images

  • Anti-CES2 antibody (ab111751) at 1/100 dilution + MCF7 cell lysates at 35 µg

    Predicted band size : 62 kDa
  • Immunohistochemistry analysis of CES2 expression in formalin fixed and paraffin embedded Human hepatocarcinoma tissue using 1/50 ab111751 followed by a peroxidase conjugated secondary antibody and DAB staining.

References

ab111751 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you very much for your interest in ab111751.

The immunogen sequence for this product is from aa 343 to aa 373 of the Human CES2: NNEFGWLI PKVMRIYDTQ KEMDREASQA ALQ.

To our knowledge, ab111751 has only been tested in Human. The...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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