Overview

  • Product nameAnti-CFHR5 antibodySee all CFHR5 primary antibodies ...
  • Description
    Rabbit polyclonal to CFHR5
  • Tested applicationsWB, IP more details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-569 of Human CFHR5 (NP_110414.1).

  • Positive control
    • CFHR5 transfected 293T cell line.

Properties

Applications

Our Abpromise guarantee covers the use of ab118122 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB 1/1000. Predicted molecular weight: 64 kDa.
IP Use at an assay dependent dilution.

Target

  • FunctionInvolved in complement regulation.
  • Tissue specificityExpressed by the liver and secreted in plasma.
  • Involvement in diseaseNote=Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. Atypical hemolytic uremic syndrome is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.
  • Sequence similaritiesContains 9 Sushi (CCP/SCR) domains.
  • Cellular localizationSecreted.
  • Target information above from: UniProt accession Q9BXR6 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
  • Alternative names
    • CFHL5 antibody
    • CFHR5 antibody
    • CFHR5D antibody
    • Complement factor H-related 5 antibody
    • Complement factor H-related protein 5 antibody
    • factor H-related gene 5 antibody
    • factor H-related protein 5 antibody
    • FHR-5 antibody
    • FHR5 antibody
    • FHR5_HUMAN antibody
    • FLJ10549 antibody
    • MGC133240 antibody
    • OTTHUMP00000034672 antibody
    see all

Anti-CFHR5 antibody images

  • All lanes : Anti-CFHR5 antibody (ab118122) at 1/1000 dilution

    Lane 1 : 293T cell line, transfected with CFHR5
    Lane 2 : 293T cell line, non-transfected

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 64 kDa
  • Immunoprecipitation of CFHR5 transfected lysate using ab118122 antibody and Protein A Magnetic Beads, immunoblotted with ab118122.

References for Anti-CFHR5 antibody (ab118122)

ab118122 has not yet been referenced specifically in any publications.

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