• Product nameAnti-CGRP antibody
    See all CGRP primary antibodies
  • Description
    Sheep polyclonal to CGRP
  • SpecificityOn rat spinal cord immunostaining may be abolished by preincubation with 10nmol CGRP (rat alpha) per mL diluted antiserum. Neither substance P nor galanin have any effect on immunostaining when used at 10nmol/mL diluted antiserum. It is believed that ab22560 cross-reacts with all known forms of rat and human CGRP.
  • Tested applicationsSuitable for: ICC/IF, IHC-FoFrmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Rat CGRP conjugated to Keyhole Limpet Haemocyanin (KLH).

  • Positive control
    • Rat spinal cord.



Our Abpromise guarantee covers the use of ab22560 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration. PubMed: 24042033
IHC-FoFr 1/2000 - 1/4000.


  • RelevanceCGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.
  • Cellular localizationEndoplasmic reticulum and Secreted
  • Database links
  • Alternative names
    • Calcitonin/calcitonin related polypeptide alpha antibody
    • Alpha type CGRP antibody
    • Beta type CGRP antibody
    • CALC1 antibody
    • CALC2 antibody
    • CALCA antibody
    • CALCB antibody
    • Calcitonin 1 antibody
    • Calcitonin 2 antibody
    • Calcitonin gene related peptide I antibody
    • Calcitonin gene related peptide II antibody
    • Calcitonin related polypeptide alpha antibody
    • Calcitonin related polypeptide beta antibody
    • CGRP antibody
    • CGRP I antibody
    • CGRP II antibody
    • CGRP1 antibody
    • CGRP2 antibody
    • CT antibody
    • Katacalcin antibody
    • KC antibody
    see all

Anti-CGRP antibody images

  • Vibratome (70 µm) sections of rat spinal cord immunostained with sheep polyclonal antiserum to CGRP at a dilution of 1:1000. Negative images of fluorescence detection procedure (Alexa488 conjugated secondary antibody). Micrograph courtesy of Professor Andrew Todd (university of Glasgow).

References for Anti-CGRP antibody (ab22560)

This product has been referenced in:
  • Ozawa A  et al. Knock-In Mice with NOP-eGFP Receptors Identify Receptor Cellular and Regional Localization. J Neurosci 35:11682-93 (2015). Read more (PubMed: 26290245) »
  • Figueroa JD  et al. Metabolomics uncovers dietary omega-3 fatty acid-derived metabolites implicated in anti-nociceptive responses after experimental spinal cord injury. Neuroscience 255C:1-18 (2013). ICC/IF ; Rat . Read more (PubMed: 24042033) »

See all 4 Publications for this product

Product Wall

I am very pleased to hear you would like to accept our offer and test ab22560 in mouse. This code will give you 1 free mouse before the expiration date. To redeem this offer, please submit an Abreview for mouse and include this code in the “Additional ...

Read More

Thank you for your enquiry. I have examined each of the antibodies against one another with respect to your application of ICC in murine cells. ab10987 is a monoclonal antiserum that recognizes 10 amino acids in the C-terminus and recognizes hu...

Read More