Overview

  • Product name
  • Description
    Rabbit polyclonal to CHAC1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 38-254 of Human CHAC1 (UniProt ID: Q9BUX1).

  • Positive control
    • HeLa cells treated with tunicamycin at 4µg/ml for 12 and 24 hours

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab155533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.

Target

  • Function
    Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
  • Sequence similarities
    Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
  • Cellular localization
    Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network.
  • Information by UniProt
  • Database links
  • Alternative names
    • Blocks Notch protein antibody
    • Botch antibody
    • Cation transport regulator like protein 1 antibody
    • Cation transport regulator-like protein 1 antibody
    • ChaC antibody
    • ChaC cation transport regulator homolog 1 antibody
    • ChaC cation transport regulator like 1 antibody
    • chac1 antibody
    • CHAC1_HUMAN antibody
    • Gamma GCT acting on glutathione homolog 1 antibody
    • Gamma-GCG 1 antibody
    • Glutathione-specific gamma-glutamylcyclotransferase 1 antibody
    see all

Images

  • Anti-CHAC1 antibody (ab155533) at 1/500 dilution + HeLa whole cell lysate treated with tunicamycin (4µg/ml) at 30 µg

    Predicted band size : 28 kDa

References

ab155533 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab155533.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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