Overview

  • Product name
  • Description
    Rabbit polyclonal to CHD1L
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within internal sequence amino acids 274-598 of Human CHD1L (Uniprot ID: Q86WJ1).

  • Positive control
    • HepG2 whole cell and nuclear lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 79% PBS, 20% Glycerol
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab155669 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 101 kDa.

Target

  • Function
    DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.
  • Tissue specificity
    Frequently overexpressed in hepatomacellular carcinomas.
  • Sequence similarities
    Belongs to the SNF2/RAD54 helicase family.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
    Contains 1 Macro domain.
  • Domain
    The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
  • Cellular localization
    Nucleus. Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.
  • Information by UniProt
  • Database links
  • Alternative names
    • ALC1 antibody
    • Amplified in liver cancer 1 antibody
    • Amplified in liver cancer protein 1 antibody
    • chd1l antibody
    • CHD1L_HUMAN antibody
    • CHDL antibody
    • Chromodomain helicase DNA binding protein 1 like antibody
    • Chromodomain-helicase-DNA-binding protein 1-like antibody
    • FLJ22530 antibody
    see all

Images

  • All lanes : Anti-CHD1L antibody (ab155669) at 1/3000 dilution

    Lane 1 : HepG2 whole cell lysate
    Lane 2 : HepG2 nuclear lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 101 kDa



    5% SDS PAGE

References

ab155669 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab155669.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Sign up