The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. 1-3µl/106cells/50-100µl.
FunctionReceptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3.
Tissue specificityExpressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Staining of murine 300-19 cells stably expressing either transfected human CCR7 (upper panel) or human Chemokine Receptor D6 (lower panel) with ab1658 (grey) and peptide blocked ab1658 (black line).
References for Anti-Chemokine Receptor D6 antibody (ab1658)
This product has been referenced in:
Neil SJ et al. The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. J Virol79:9618-24 (2005).
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