Overview

  • Product name
    Anti-Chemokine Receptor D6 antibody
    See all Chemokine Receptor D6 primary antibodies
  • Description
    Goat polyclonal to Chemokine Receptor D6
  • Specificity
    Peptide sequence is < 50 % identical to other human chemokine receptors in this region.
  • Tested applications
    Suitable for: ELISA, Flow Cyt, ICC, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-LATEDADSENSSFYYYDYLDEVAFML

    , corresponding to N terminal amino acids 10-35 of Human Chemokine Receptor D6

  • Positive control
    • Human spleen cells.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab1658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/100000.
Flow Cyt Use at an assay dependent concentration. 1-3µl/106cells/50-100µl.

ICC 1/400.
IHC-P 1/250.
WB 1/1000.

Target

  • Function
    Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3.
  • Tissue specificity
    Expressed primarily in placenta and fetal liver, and found at very low levels in the lung and lymph node. Found in endothelial cells lining afferent lymphatics in dermis and lymph nodes. Also found in lymph nodes subcapsular and medullary sinuses, tonsillar lymphatic sinuses and lymphatics in mucosa and submucosa of small and large intestine and appendix. Also found in some malignant vascular tumors.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C C chemokine receptor D6 antibody
    • C-C chemokine receptor D6 antibody
    • CC chemokine binding receptor JAB61 antibody
    • CC chemokine receptor D6 antibody
    • CCBP 2 antibody
    • CCBP2 antibody
    • CCBP2_HUMAN antibody
    • CCR 10 antibody
    • CCR 9 antibody
    • CCR10 antibody
    • CCR9 antibody
    • Chemokine (C C motif) receptor 9 antibody
    • Chemokine (C C) receptor 9 antibody
    • Chemokine binding protein 2 antibody
    • Chemokine binding protein D6 antibody
    • Chemokine C C motif receptor 9 antibody
    • Chemokine C C receptor 9 antibody
    • Chemokine CC motif receptor 9 antibody
    • Chemokine CC receptor 9 antibody
    • Chemokine receptor 9 antibody
    • Chemokine receptor CCR 10 antibody
    • Chemokine receptor CCR 9 antibody
    • Chemokine receptor CCR-10 antibody
    • Chemokine receptor CCR-9 antibody
    • Chemokine receptor CCR10 antibody
    • Chemokine receptor CCR9 antibody
    • Chemokine receptor D6 antibody
    • Chemokine-binding protein 2 antibody
    • Chemokine-binding protein D6 antibody
    • CMKBR 9 antibody
    • CMKBR9 antibody
    • D6 antibody
    • hD6 antibody
    • MGC126678 antibody
    • MGC138250 antibody
    see all

Images

  • Immunohistochemistry on paraffin section of human spleen, at 1/250 dilution.
  • Staining of murine 300-19 cells stably expressing either transfected human CCR7 (upper panel) or human Chemokine Receptor D6 (lower panel) with ab1658 (grey) and peptide blocked ab1658 (black line).

References

This product has been referenced in:
  • Neil SJ  et al. The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. J Virol 79:9618-24 (2005). Read more (PubMed: 16014924) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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