Overview

  • Product nameAnti-Chimaerin 2 antibody
    See all Chimaerin 2 primary antibodies
  • Description
    Rabbit polyclonal to Chimaerin 2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide selective for Chimaerin 2 protein. The peptide was post-synthetically modified and conjugated to a carrier protein before used for immunization of rabbits.

  • Positive control
    • Chimaerin 2 samples.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferConstituents: Antibody stabilization buffer with preservative.
  • Concentration information loading...
  • PurityProtein A purified
  • Purification notesab59625 was affinity purified on an immobilized antigen based affinity chromatography.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab59625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 50 kDa (predicted molecular weight: 54 kDa).

Target

  • RelevanceThe Chimaerin gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, an SH2 domain and a Rho-GAP domain. This protein has GTPase-activating protein activity which is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Increased expression of this gene is associated with lymphomas and decreased expression of this gene is associated with high-grade gliomas and breast tumors. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Cellular localizationMembrane; Peripheral membrane protein
  • Database links
  • Alternative names
    • ARHGAP3 antibody
    • BCH antibody
    • Beta chimerin antibody
    • Chimaerin2 antibody
    • Chimerin (chimaerin) 2 antibody
    • Chimerin 2 antibody
    • CHN 2 antibody
    • CHN2 antibody
    • MGC138360 antibody
    • Rho GTPase activating protein 3 antibody
    • RHOGAP3 antibody
    see all

References for Anti-Chimaerin 2 antibody (ab59625)

This product has been referenced in:
  • Paul C & Robaire B Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases. PLoS One 8:e84354 (2013). WB ; Rat . Read more (PubMed: 24391944) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab59625.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"