Overview

  • Product name
  • Description
    Rabbit polyclonal to Chimaerin 2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide selective for Chimaerin 2 protein. The peptide was post-synthetically modified and conjugated to a carrier protein before used for immunization of rabbits.

  • Positive control
    • Chimaerin 2 samples.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer
    Constituents: Antibody stabilization buffer with preservative.
  • Concentration information loading...
  • Purity
    Protein A purified
  • Purification notes
    ab59625 was affinity purified on an immobilized antigen based affinity chromatography.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab59625 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 50 kDa (predicted molecular weight: 54 kDa).

Target

  • Relevance
    The Chimaerin gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, an SH2 domain and a Rho-GAP domain. This protein has GTPase-activating protein activity which is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Increased expression of this gene is associated with lymphomas and decreased expression of this gene is associated with high-grade gliomas and breast tumors. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Cellular localization
    Membrane; Peripheral membrane protein
  • Database links
  • Alternative names
    • ARHGAP3 antibody
    • BCH antibody
    • Beta chimerin antibody
    • Chimaerin2 antibody
    • Chimerin (chimaerin) 2 antibody
    • Chimerin 2 antibody
    • CHN 2 antibody
    • CHN2 antibody
    • MGC138360 antibody
    • Rho GTPase activating protein 3 antibody
    • RHOGAP3 antibody
    see all

References

This product has been referenced in:
  • Paul C & Robaire B Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases. PLoS One 8:e84354 (2013). WB ; Rat . Read more (PubMed: 24391944) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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