Anti-Chlamydia trachomatis LPS antibody [1312/236] (ab54377)

Overview

  • Product nameAnti-Chlamydia trachomatis LPS antibody [1312/236]
    See all Chlamydia trachomatis LPS primary antibodies
  • Description
    Mouse monoclonal [1312/236] to Chlamydia trachomatis LPS
  • SpecificityIn a simple ELISA this antibody is reactive with 15 serovars of C. trachomatis.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Chlamydia trachomatis
  • Immunogen

    Native Chlamydia trachomatis LPS

  • EpitopeThe epitope has been shown by Western blotting to be present in LPS.

Properties

Applications

Our Abpromise guarantee covers the use of ab54377 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesELISA: Use at an assay dependent dilution.
    WB: Use at an assay dependent dilution.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceLPS is a major component of the cell membrane of Gram negative bacteria, contributing greatly to the structural integrity of the bacteria, and protecting the membrane from certain kinds of chemical attack. LPS is an endotoxin, inducing a strong response from normal animal immune systems. LPS function has been under experimental research for several years due to its role in activating many transcriptional factors, which become active after stimulation with LPS. LPS also induces many types of mediators involved in septic shock. Chlamydia trachomatis is an intracellular organism. It has a genome size of approximately 500-1000kB and contains both RNA and DNA. Colonization of Chlamydia begins with attachment to sialic acid receptors on the eye, throat or genitalia. It persists at body sites that are inaccessible to phagocytes, T-cells, and B-cells. It also exists as 15 different serotypes. These serotypes cause four major diseases in humans: endemic trachoma (caused by serotypes A and C), sexually transmitted disease and inclusion conjunctivitis (caused by serotypes D and K), and lymphogranuloma venereum (caused by serotypes L1, L2, and L3). Studies reveal that Chlamydia, because of its cell wall, is able to inhibit phagolysosome fusion in phagocytes. The cell wall is proposed to be gram-negative in that it contains an outer lipopolysaccharide (LPS) membrane, but it lacks peptidoglycan in its cell wall.
    • Alternative names
      • C.trachomatis antibody

    References for Anti-Chlamydia trachomatis LPS antibody [1312/236] (ab54377)

    ab54377 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your inquiry and your patience with this request.   I have received additional information from the lab. The MW of LPS will be dependent on the strain and species of bacteria used, so an exact MW is not given. LPS is a polymer and by ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"