Overview

  • Product nameAnti-CHMP1B antibody
    See all CHMP1B primary antibodies
  • Description
    Rabbit polyclonal to CHMP1B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Cat, Drosophila melanogaster, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 35-84 (KIKKAIQKGN MEVARIHAEN AIRQKNQAVN FLRMSARVDA VAARVQTAVT) of Human CHMP1B (NP_065145).

  • Positive control
    • Human fetal heart lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab105706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionProbable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.
  • Tissue specificityWidely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain.
  • Sequence similaritiesBelongs to the SNF7 family.
  • Cellular localizationCytoplasm > cytosol. Endosome. Late endosome membrane. Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2810405I11Rik antibody
    • C10orf2 antibody
    • C18 ORF2 antibody
    • C18orf2 antibody
    • Charged multivesicular body protein 1b antibody
    • CHM1B_HUMAN antibody
    • CHMP family, member 1B antibody
    • CHMP1.5 antibody
    • CHMP1b antibody
    • Choromosome 18 open reading frame 2 antibody
    • Chromatin-modifying protein 1b antibody
    • hVps46-2 antibody
    • vacuolar protein sorting 46-2 antibody
    • Vacuolar protein sorting-associated protein 46-2 antibody
    • Vps46-2 antibody
    • Vps46B antibody
    see all

Anti-CHMP1B antibody images

  • Anti-CHMP1B antibody (ab105706) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Predicted band size : 22 kDa

References for Anti-CHMP1B antibody (ab105706)

ab105706 has not yet been referenced specifically in any publications.

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