Overview

  • Product nameAnti-CHMP4A antibody
    See all CHMP4A primary antibodies
  • Description
    Rabbit polyclonal to CHMP4A
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 210-259 (ELEQEELAQE LLNVGDKEEE PSVKLPSVPS THLPAGPAPK VDEDEEALKQ) of Human CHMP4A (NP_054888).

  • Positive control
    • 721_B cell lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferConstituents: 98% PBS, 2% Sucrose
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab116340 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 25 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • RelevanceComponent of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In the ESCRT-III complex, it probably serves as an acceptor for ESCRT-I complex on endosomal membranes. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargos of viral proteins, via the association of CHMP4 proteins with PDCD6IP/AIP1, a protein directly recruited by HIV-1 p6 protein that functions at sites of viral Gag assembly and budding.
  • Cellular localizationCytoplasmic: Cytoplasmic vesicle membrane. Membrane-associated - localizes to large vesicle-like structures.
  • Database links
  • Alternative names
    • C14orf123 antibody
    • Charged multivesicular body protein 4a antibody
    • Chromatin modifying protein 4a antibody
    • HSPC134 antibody
    • SHAX2 antibody
    see all

Anti-CHMP4A antibody images

  • Anti-CHMP4A antibody (ab116340) at 1 µg/ml + 721_B cell lysate at 10 µg

    Predicted band size : 25 kDa

References for Anti-CHMP4A antibody (ab116340)

ab116340 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"