Overview

  • Product nameAnti-Cholecystokinin 39 antibody
  • Description
    Rabbit polyclonal to Cholecystokinin 39
  • Specificityab22530 detects Cholecystokinin (CCK) peptide. Please note that this antiserum detects endocrine cells, but is not suitable for use to immunostain CCK-ergic neurons.
  • Tested applicationsSuitable for: Electron Microscopy, IHC-Fr, IHC-R, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Pig, Cynomolgus Monkey
  • Immunogen

    Synthetic peptide:

    VLMAVLAAGALT

    conjugated to Ovalbumin by a Glutaraldehyde linker, corresponding to amino acids 9-20 of Cholecystokinin 39.

  • Positive control
    • Human, rat and pig intestine (jejunum)

Properties

Applications

Our Abpromise guarantee covers the use of ab22530 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Electron Microscopy
IHC-Fr
IHC-R
IHC-P
  • Application notesElectron Microscopy:
    IHC-Fr:
    IHC-P:
    IHC-R:
    Notes: Dilution Range-1:200 - 1:800, using overnight incubation and indirect immunofluorescence procedure. 1:500 - 1:2500 using overnight incubation and indirect immunoperoxidase procedure (such as PAP, immunogold or ABC).
    Dilute to working strength with phosphate buffered saline (PBS) containing 0.1% Sodium Azide.
    Is not suitable for use to immunostain CCKergic neurones.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceCholecystokinin (CCK) is one of the most important hormone regulators of the digestive process. The peptide is concentrated in the proximal small intestine (CCK cells) and is secreted into the blood in response to the ingestion of proteins and fats, where its actions include the stimulation of pancreatic secretion, the modulation of insulin output, the regulation of gastric emptying, and gallbladder contraction. In the central nervous system CCKergic fibres are widespread, being particularly abundant in the cerebral cortex. In some mesolimbic neurons projecting to the nucleus accumbens, CCK is colocalised with dopamine and it has been suggested that CCK might facilitate the function of dopamine in events such as stimulusreward associative behaviour. Secretion of CCK from the murine tumour cell line STC1 has been shown to be stimulated by pituitary adenylate cyclase activating protein (PACAP) and has raised the possibility that PACAP may function as a neuromodulator of CCK release from gut endocrine cells in vivo.
    • Cellular localizationSecreted
    • Database links
    • Alternative names
      • CCK antibody
      • CCK39 antibody
      • Cholecystokinin 39 antibody
      • Cholecystokinin antibody

    References for Anti-Cholecystokinin 39 antibody (ab22530)

    ab22530 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"