Overview

  • Product name
  • Description
    Rabbit polyclonal to CHREBP
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 623-653 of Human CHREBP (NP_116569.1, NP_116570.1, NP_116571.1, NP_116572.1).

  • Positive control
    • NCI-H292 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab112944 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 93 kDa.

Target

  • Function
    Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'.
  • Tissue specificity
    Expressed in liver, heart, kidney, cerebellum and intestinal tissues.
  • Involvement in disease
    Note=WBSCR14 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of WBSCR14 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
  • Sequence similarities
    Contains 1 basic helix-loop-helix (bHLH) domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • carbohydrate response element binding protein antibody
    • bHLHd14 antibody
    • Carbohydrate responsive element binding protein antibody
    • Class D basic helix-loop-helix protein 14 antibody
    • MIO antibody
    • MLX interacting protein like antibody
    • Mlx interactor antibody
    • MLX-interacting protein-like antibody
    • MLXIPL antibody
    • MONDOB antibody
    • WBS14_HUMAN antibody
    • WBSCR 14 antibody
    • WBSCR14 antibody
    • Williams Beuren syndrome chromosome region 14 antibody
    • Williams Beuren syndrome chromosome region 14 protein antibody
    • Williams-Beuren syndrome chromosomal region 14 protein antibody
    • WS basic helix loop helix leucine zipper protein antibody
    • WS basic-helix-loop-helix leucine zipper protein antibody
    • WS bHLH antibody
    • WS-bHLH antibody
    see all

Images

  • Anti-CHREBP antibody (ab112944) at 1/100 dilution + NCI-H292 cell line lysates at 35 µg

    Predicted band size : 93 kDa

References

This product has been referenced in:
  • Airley RE  et al. Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression. Br J Cancer 110:715-23 (2014). Human . Read more (PubMed: 24366300) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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