FunctionIonotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
Tissue specificityExpressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes.
Sequence similaritiesBelongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-10/CHRNA10 sub-subfamily.
All lanes : Anti-CHRNA10 antibody (ab110063) at 1/500 dilution
Lane 1 : Extracts from A549 cells Lane 2 : Extracts from COLO cells Lane 3 : Extracts from 293 cells Lane 4 : Extracts from HeLa cells Lane 5 : Extracts from A549 cells with immunising peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Predicted band size : 50 kDa
References for Anti-CHRNA10 antibody (ab110063)
has not yet been referenced specifically in any publications.
Publishing research using ab110063? Please let us know so that we can cite the reference in this datasheet.
Concentration of lot no. is
Concentration not available for this lot.
Find concentration of your lot:
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"