Overview

  • Product nameAnti-CHST14 antibody
  • Description
    Rabbit polyclonal to CHST14
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 177-205 of Human CHST14 (NP_569735.1).

  • Positive control
    • Mouse stomach tissue lysates.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab116308 is purified through a protein A column, followed by peptide affinity purification.
  • ClonalityPolyclonal
  • IsotypeIgG

Applications

Our Abpromise guarantee covers the use of ab116308 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 43 kDa.

Target

  • FunctionCatalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA.
  • Tissue specificityWidely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid.
  • Involvement in diseaseDefects in CHST14 are the cause of Ehlers-Danlos syndrome musculocontractural type (EDSMC) [MIM:601776]. It is a form of Ehlers-Danlos syndrome characterized by distinctive craniofacial dysmorphism, congenital contractures of thumbs and fingers, clubfeet, severe kyphoscoliosis, muscular hypotonia, hyperextensible thin skin with easy bruisability and atrophic scarring, wrinkled palms, joint hypermobility, and ocular involvement.
  • Sequence similaritiesBelongs to the sulfotransferase 2 family.
  • Cellular localizationGolgi apparatus membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2600016L03Rik antibody
    • ATCS antibody
    • Carbohydrate (N acetylgalactosamine 4 0) sulfotransferase 14 antibody
    • Carbohydrate sulfotransferase 14 antibody
    • CHST14 antibody
    • CHSTE_HUMAN antibody
    • D4ST-1 antibody
    • D4st1 antibody
    • Dermatan 4-sulfotransferase 1 antibody
    • hD4ST1 antibody
    • RP23-286G12.2 antibody
    • UNQ1925/PRO4400 antibody
    see all

Anti-CHST14 antibody images

  • Anti-CHST14 antibody (ab116308) at 1/100 dilution + Mouse stomach tissue lysates at 15 µg

    Predicted band size : 43 kDa

References for Anti-CHST14 antibody (ab116308)

ab116308 has not yet been referenced specifically in any publications.

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