• Product nameAnti-CHX10 antibody - ChIP Grade
    See all CHX10 primary antibodies
  • Description
    Sheep polyclonal to CHX10 - ChIP Grade
  • Tested applicationsSuitable for: WB, ChIP, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Cow, Human
  • Immunogen

    Recombinant fragment, corresponding to N terminal amino acids 1-131 of Human CHX10.

  • Positive control
    • Rat or mouse retinal tissue lysate.



Our Abpromise guarantee covers the use of ab16142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 46 kDa. Detects a band of approximately 46 kDa mouse and rat retinal tissue lysates.
ChIP Use at an assay dependent dilution. PubMed: 18272592
IHC-P Use at an assay dependent concentration. PubMed: 20459797


  • FunctionPlays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.
  • Tissue specificityAbundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate.
  • Involvement in diseaseDefects in VSX2 are the cause of microphthalmia isolated type 2 (MCOP2) [MIM:610093]; also known as isolated clinical anophthalmia. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.
    Defects in VSX2 are the cause of microphthalmia with cataracts and iris abnormalities (MCOPCTI) [MIM:610092].
    Defects in VSX2 are the cause of microphthalmia isolated with coloboma type 3 (MCOPCB3) [MIM:610092]; also known as isolated colobomatous microphthalmia 3. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure).
  • Sequence similaritiesBelongs to the paired homeobox family.
    Contains 1 CVC domain.
    Contains 1 homeobox DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C elegans ceh 10 homeo domain containing homolog antibody
    • Ceh 10 homeo domain containing homolog (C. elegans) antibody
    • Ceh 10 homeo domain containing homolog antibody
    • Ceh 10 homeodomain containing homolog antibody
    • Ceh 10 homeodomain containing homolog (C. elegans) antibody
    • Ceh-10 homeodomain-containing homolog antibody
    • Ceh10 homeo domain containing homolog antibody
    • Ceh10 homeodomain containing homolog antibody
    • CHX 10 antibody
    • Homeobox protein CHX 10 antibody
    • Homeobox protein CHX10 antibody
    • HOX 10 antibody
    • HOX10 antibody
    • MCOP 2 antibody
    • MCOP2 antibody
    • MCOPCB 3 antibody
    • MCOPCB3 antibody
    • RET 1 antibody
    • RET1 antibody
    • Visual system homeobox 2 antibody
    • Vsx 2 antibody
    • Vsx2 antibody
    • VSX2_HUMAN antibody
    see all

Anti-CHX10 antibody - ChIP Grade images

  • Western blot analysis using ab161412 at 1 µg/ml on rat liver (A), rat retina tissue lysate (B), mouse liver (C) and mouse retina tissue lysate (D).

References for Anti-CHX10 antibody - ChIP Grade (ab16142)

This product has been referenced in:
  • Rapicavoli NA  et al. The long noncoding RNA RNCR2 directs mouse retinal cell specification. BMC Dev Biol 10:49 (2010). IHC-P ; Mouse . Read more (PubMed: 20459797) »
  • Bharti K  et al. Alternative promoter use in eye development: the complex role and regulation of the transcription factor MITF. Development 135:1169-78 (2008). ChIP ; Mouse . Read more (PubMed: 18272592) »

See all 2 Publications for this product

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