Overview

  • Product nameAnti-CIB1 antibody [1D1]
    See all CIB1 primary antibodies
  • Description
    Mouse monoclonal [1D1] to CIB1
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length human CIB1, purified from E. coli

  • Positive control
    • HT29 cell lysate.
  • General notes


    This antibody was derived from the hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice.

Properties

Applications

Our Abpromise guarantee covers the use of ab66954 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
ELISA Use at an assay dependent dilution.

Target

  • FunctionMay convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
  • Tissue specificityUbiquitous.
  • Sequence similaritiesContains 2 EF-hand domains.
  • Cellular localizationMembrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Calcium and integrin binding 1 (calmyrin) antibody
    • Calcium and integrin binding protein 1 antibody
    • Calcium and integrin-binding protein 1 antibody
    • Calcium- and integrin-binding protein antibody
    • Calmyrin antibody
    • CIB antibody
    • CIB1 antibody
    • CIB1_HUMAN antibody
    • CIBP antibody
    • DNA PKcs interacting protein antibody
    • DNA-dependent protein kinase interacting protein antibody
    • DNA-PK interaction protein antibody
    • DNA-PKcs-interacting protein antibody
    • Human Snk interacting protein 2 to 28 mRNA complete cds antibody
    • Kinase interacting protein antibody
    • Kinase-interacting protein 1 antibody
    • Kinase-interacting protein antibody
    • KIP antibody
    • KIP1 antibody
    • PRKDCIP antibody
    • SIP2 28 antibody
    • SIP2-28 antibody
    • SNK interacting protein 2 to 28 antibody
    • SNK-interacting protein 2-28 antibody
    see all

Anti-CIB1 antibody [1D1] images

  • Anti-CIB1 antibody [1D1] (ab66954) at 1/1000 dilution + HT29 cell lysate at 40 µg

    Secondary
    goat anti-mouse
    Developed using the ECL technique

    Predicted band size : 22 kDa
    Observed band size : 22 kDa

References for Anti-CIB1 antibody [1D1] (ab66954)

ab66954 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"