Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab43133 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).

Target

  • Function
    May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
  • Tissue specificity
    Ubiquitous.
  • Sequence similarities
    Contains 2 EF-hand domains.
  • Cellular localization
    Membrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Calcium and integrin binding 1 (calmyrin) antibody
    • Calcium and integrin binding protein 1 antibody
    • Calcium and integrin-binding protein 1 antibody
    • Calcium- and integrin-binding protein antibody
    • Calmyrin antibody
    • CIB antibody
    • CIB1 antibody
    • CIB1_HUMAN antibody
    • CIBP antibody
    • DNA PKcs interacting protein antibody
    • DNA-dependent protein kinase interacting protein antibody
    • DNA-PK interaction protein antibody
    • DNA-PKcs-interacting protein antibody
    • Human Snk interacting protein 2 to 28 mRNA complete cds antibody
    • Kinase interacting protein antibody
    • Kinase-interacting protein 1 antibody
    • Kinase-interacting protein antibody
    • KIP antibody
    • KIP1 antibody
    • PRKDCIP antibody
    • SIP2 28 antibody
    • SIP2-28 antibody
    • SNK interacting protein 2 to 28 antibody
    • SNK-interacting protein 2-28 antibody
    see all

Images

  • Anti-CIB1 antibody (ab43133) at 1 µg/ml + Recombinant Human CIB1 protein (ab40628) at 0.1 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) (ab65484) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size : 22 kDa
    Observed band size : 22 kDa


    Exposure time : 30 seconds

References

ab43133 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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