Overview

  • Product nameAnti-CIB1 antibody
    See all CIB1 primary antibodies
  • Description
    Mouse monoclonal to CIB1
  • Tested applicationsSuitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-192 of Human CIB1

Properties

Applications

Our Abpromise guarantee covers the use of ab56664 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
    • Tissue specificityUbiquitous.
    • Sequence similaritiesContains 2 EF-hand domains.
    • Cellular localizationMembrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
    • Information by UniProt
    • Database links
    • Alternative names
      • Calcium and integrin binding 1 (calmyrin) antibody
      • Calcium and integrin binding protein 1 antibody
      • Calcium and integrin-binding protein 1 antibody
      • Calcium- and integrin-binding protein antibody
      • Calmyrin antibody
      • CIB antibody
      • CIB1 antibody
      • CIB1_HUMAN antibody
      • CIBP antibody
      • DNA PKcs interacting protein antibody
      • DNA-dependent protein kinase interacting protein antibody
      • DNA-PK interaction protein antibody
      • DNA-PKcs-interacting protein antibody
      • Human Snk interacting protein 2 to 28 mRNA complete cds antibody
      • Kinase interacting protein antibody
      • Kinase-interacting protein 1 antibody
      • Kinase-interacting protein antibody
      • KIP antibody
      • KIP1 antibody
      • PRKDCIP antibody
      • SIP2 28 antibody
      • SIP2-28 antibody
      • SNK interacting protein 2 to 28 antibody
      • SNK-interacting protein 2-28 antibody
      see all

    Anti-CIB1 antibody images

    • CIB1 antibody (ab56664) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.
    • Western blot against tagged recombinant protein immunogen using ab56664 CIB1 antibody at 1ug/ml. Predicted band size of immunogen is 47 kDa

    References for Anti-CIB1 antibody (ab56664)

    This product has been referenced in:
    • Raab M  et al. Differential binding of ICln in platelets to integrin-derived activating and inhibitory peptides. Biochem Biophys Res Commun 392:258-63 (2010). WB ; Human . Read more (PubMed: 20034469) »

    See 1 Publication for this product

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    There are currently no Abreviews or Questions for ab56664.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"