Recombinant
RabMAb

Anti-CILP antibody [EPR16303] (ab192881)

Overview

  • Product name
    Anti-CILP antibody [EPR16303]
  • Description
    Rabbit monoclonal [EPR16303] to CILP
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human CILP aa 1-100. The exact sequence is proprietary.
    Database link: O75339

  • Positive control
    • Human cartilage lysate
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab192881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 90 kDa (predicted molecular weight: 133 kDa).

Target

  • Function
    Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.
  • Tissue specificity
    Specifically expressed in cartilage. Localizes in the intermediates layer of articular cartilage but neither in the superficial nor in the deepest regions. Specifically and highly expressed in intervertebral disk tissue. Expression increases with aging in hip articular cartilage. Overexpressed in articular hyaline cartilage from patients with calcium pyrophosphate dihydrate crystal deposition disease (CPPD). Expression in intervertebral disk tissue from individuals with lumbar disk disease increases as disk degeneration progresses.
  • Involvement in disease
    Defects in CILP are a cause of susceptibility to intervertebral disk disease (IDD) [MIM:603932]. A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Note=Susceptibility to intervertebral disk disease, is conferred by variant p.Ile395Thr (PubMed:15864306).
  • Sequence similarities
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 1 TSP type-1 domain.
  • Post-translational
    modifications
    Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion.
  • Cellular localization
    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links
  • Alternative names
    • Cartilage intermediate layer protein 1 antibody
    • Cartilage intermediate layer protein 1 C1 antibody
    • Cartilage intermediate layer protein 1 C2 antibody
    • cartilage intermediate layer protein antibody
    • cartilage intermediate layer protein, nucleotide pyrophosphohydrolase antibody
    • Cartilage intermediate-layer protein antibody
    • CILP 1 antibody
    • CILP antibody
    • CILP-1 antibody
    • CILP1_HUMAN antibody
    • HGNC:1980 antibody
    • HsT18872 antibody
    see all

Images

  • Anti-CILP antibody [EPR16303] (ab192881) at 1/5000 dilution + Human cartilage lysate at 10 µg

    Secondary
    Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

    Predicted band size : 133 kDa
    Observed band size : 90 kDa (why is the actual band size different from the predicted?)

References

ab192881 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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