FunctionProbably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.
Tissue specificityLocalized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart.
Sequence similaritiesBelongs to the cingulin family.
DomainDeletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1.
Cellular localizationCell junction > tight junction. Localizes to the apical junction complex composed of tight and adherens junctions.
ab117796 at 1 µg/ml staining Cingulin in 293T cell lysate immunoprecipitated using ab117796 at 6 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection: Chemiluminescence with exposure time of 3 seconds
References for Anti-Cingulin antibody (ab117796)
has not yet been referenced specifically in any publications.
Publishing research using ab117796? Please let us know so that we can cite the reference in this datasheet.
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