Overview

  • Product name
  • Description
    Rabbit polyclonal to CINP
  • Tested applications
    Suitable for: WB, Flow Cytmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human CINP (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q9BW66

  • Positive control
    • CEM cells and lysates.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab176181 is purified through a protein A column, followed by peptide affinity purification.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab176181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 24 kDa.
Flow Cyt 1/10 - 1/50. ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

Target

  • Function
    Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling.
  • Sequence similarities
    Belongs to the CINP family.
  • Post-translational
    modifications
    Phosphorylated by CDC7 but not by CDK2.
  • Cellular localization
    Nucleus. Binds to nuclear under G1 conditions, and dissociates from chromatin with the start of DNA replication.
  • Information by UniProt
  • Database links
  • Alternative names
    • CDK2-interacting protein antibody
    • CINP antibody
    • CINP protein antibody
    • CINP_HUMAN antibody
    • Cyclin dependent kinase 2 interacting protein antibody
    • Cyclin-dependent kinase 2-interacting protein antibody
    • MGC849 antibody
    see all

Images

  • Anti-CINP antibody (ab176181) at 1/1000 dilution + CEM cell lysate at 35 µg

    Predicted band size : 24 kDa
  • Flow cytometric analysis of CEM cells labeling CINP with ab176181 at 1/10 dilution (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-Rabbit secondary antibodies were used for the analysis.

References

ab176181 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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